This is perhaps the most underrated piece of the puzzle. Research has shown that estrogen stimulates the production of GLP-1 in the intestine and pancreas. Estrogen stimulates the release of GLP-1 by activating specific receptors. As estrogen declines during perimenopause, GLP-1 signaling also weakens, creating a domino effect of increased hunger, fat accumulation, especially around the belly, and difficulty managing blood sugar, even if your habits haven’t changed. Microdosing GLP-1 can be understood, in part, as replacing a signaling pathway that your body is losing.
Gn Health
