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Christina Applegate misdiagnosed with MS: 'Really confusing'
Entertainment

Christina Applegate misdiagnosed with MS: ‘Really confusing’

By Mix9p
October 20, 2026 2 Min Read
Comments Off on Christina Applegate misdiagnosed with MS: ‘Really confusing’

Emmy winner Christina Applegate’s health journey took an unexpected turn, years after her public battle with a disease she thought was multiple sclerosis.

Applegate, 54, is “back to square one” after learning she was misdiagnosed with MS, the “Dead to Me” and “Samantha Who?” The TV star revealed this on Tuesday’s episode of her podcast “MeSsy.”

“I wasn’t happy at all,” Applegate told co-host Jamie-Lynn Sigler and listeners about her doctor’s recent revelation. “There’s no misdiagnosis and all of a sudden I’m better. I haven’t gotten better. If anything, I’ve gotten worse in some ways.”

Applegate, who recently returned to the spotlight after a lengthy hospital stay this year, revealed her multiple sclerosis diagnosis in 2021. MS is an autoimmune disease that affects the central nervous system and can lead to progressive physical and cognitive decline. Since her diagnosis, Applegate has spoken openly about her symptoms – including depression and “severe pain” – and channeled her experiences with the illness into a memoir titled “You With the Sad Eyes.”

Christina Applegate misdiagnosed with MS: 'Really confusing'

Applegate became emotional during the podcast episode when she recalled learning of her misdiagnosis, saying she felt discouraged — “I don’t know what’s happening to me” — and that her doctors were going to investigate the root of her symptoms further. The actress also said that following her misdiagnosis, she felt like she had failed the MS community. The experience was disconcerting and “really confusing for me,” she added.

“Sopranos” star Sigler, who has lived with MS for more than a decade, assured his co-host that the misdiagnosis does not change Applegate’s efforts to raise awareness about MS or educate listeners. Still, Applegate said: “I’m just in shock right now. »

“I don’t feel relieved,” she said later in the podcast episode.

Amid reports of her prolonged hospital stay earlier this year, Applegate assured her fans in April that she was “a strong girl, and I’m getting stronger and better every day.”

Gn entert

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