NFL Week 10 Picks and Predictions, Live and ATS: Vikings Get Kirk Cousins Shot, Bengals Stop Steelers
We can finally move on to NFL Week 10 now that the trade deadline is behind us – but that doesn’t mean we can forget what just happened at the trade deadline, either. The return of Kirk Cousins to the Minnesota Vikings is an inflection point in the NFC North, just as much as the Chicago Bears’ addition of Jeffery Simmons. We also have the Jaguars going all-in, teams like the Colts and Eagles selling big, and more teams in the middle. All of this needs to factor into our NFL picks this week.
It’s a strange slate on the schedule this week, starting with Thursday Night Football, leading up to a game in Munich and ending with one of the worst Monday Night Football matchups of the year with the Chargers and Ravens facing off. But after a solid winning week, we’re hoping for more of the same as we make our NFL Week 10 picks with straight-up and against-the-spread predictions for every game.
NFL Week 10 Picks and Predictions, Live and ATS:

NFL Game of Week 10 | Direct choice | ATS choice |
|---|---|---|
Commanders vs. Giants (TNF) | Giants | Giants -1.5 |
Patriots vs. Lions (Munich) | Lions | Lions -2.5 |
Vikings vs. Packers | Vikings | Vikings +3.5 |
Texans vs. Browns | Texans | Browns +4.5 |
Chiefs versus hawks | Chefs | Leaders -3.5 |
Dolphins vs. Colts | Colts | Foals -3.5 |
Jaguars vs. Titans | Jaguar | Jaguars -10.5 |
Panthers vs. Saints | Panthers | Panthers +2.5 |
Bills versus jets | Invoices | Bills -7.5 |
Rams vs. Cardinals | Rams | Cardinals +9.5 |
Seahawks vs. Raiders | sea hawks | Raiders +6.5 |
49ers vs. Cowboys | 49ers | 49ers -4.5 |
Steelers vs. Bengals (SNF) | Bengals | Bengals -3.5 |
Chargers vs. Ravens (MNF) | Crows | Ravens -4.5 |
The 2026 NFL picks an all-time record: 83-56 (last week 12-4) | ATS recording: 62-73-3 (last week 8-7)
Note: All lines courtesy of FanDuel Sportsbook. Game odds are updated periodically and are subject to change. If you or someone you know has a gambling problem and needs help, call 1-800-GAMBLER.
The hardest NFL Week 10 prediction to make

Pittsburgh Steelers vs. Cincinnati Bengals (-3.5)
The top of the AFC North is one of the toughest divisions to determine. Baltimore dropping out was an unexpected curveball, but even more so since the Pittsburgh Steelers have seemingly taken over. But now Aaron Rodgers and Co. can hit the road and try to prove they’re worth their salt in a matchup with the high-octane Cincinnati Bengals. This looks like a real battle of defensive strength versus offensive strength.
At the same time, I still don’t trust the Bengals defense. While Rodgers and Pittsburgh’s passing game have been somewhat unremarkable, Jaylen Warren has been a revelation and Cincinnati may not have many answers. But at the end of the day, I still take Burrow and the Bengals. The explosiveness they have shown of late with Ja’Marr Chase and Tee Higgins playing all out will be the asset, especially at home, and will provide a level of explosive plays and offensive power that the Steelers won’t be able to keep up with, even with Warren’s success.
Easiest NFL Week 10 pick on the board

Jacksonville Jaguars (-10.5) vs. Tennessee Titans
Even before the trade deadline, I probably would have been inclined to take Jacksonville at 10.5 points, even on the road against a division opponent in Tennessee. The Titans looked really out of shape beyond the close loss to Cincinnati this season and, while they didn’t participate in a fire sale at the trade deadline, this roster still isn’t remotely in a place where they’re going to be able to compete with the best teams in the NFL. The Jags were before adding Jessie Bates and Jordan Davis before Tuesday’s deadline.
More importantly, though, the Jaguars completely destroyed vastly inferior opponents. They won by 24 against the Browns in Week 1, but by 29 against the then-struggling Patriots in Week 3, by 35 against the Colts in Week 8, then by 23 on the road against Baltimore last week. Jacksonville ranks in the top three in EPA offensive and defensive efficiency per game this season and the Titans simply aren’t up to par on this one. Not only will the Jags cover, but I would bet we won’t see Trevor Lawrence play in the fourth quarter again in this game.
The choice that probably makes you scratch your head

Minnesota Vikings (+3.5) vs. Green Bay Packers
There has been a growing buzz with the Packers because of what they have been doing lately, which has undoubtedly looked impressive. They’re 6-1 in their last seven games after a 1-2 start to the season – including a loss to the Vikings in Week 1, it’s worth noting – and Jordan Love has that deep passing attack that’s working at an absurd level. However, it’s worth noting that this stretch included a game against the Caleb Williams-less Bears, the bipolar Cowboys, a loss to the Lions, a win over the defensively struggling Panthers, and the elimination of a Patriots team that struggled against good competition.
Let’s not forget how Brian Flores’ defense had everyone worried about the Packers in Week 1. Although Green Bay and Love have improved since then, there is no doubt that Minnesota still has a huge advantage when it comes to what they are capable of defensively. More importantly, though, I’m optimistic about the boost Kirk Cousins is about to give this offense and the Packers might be a little stunned by the newfound power the Vikings are finding on that side of the ball.
This seems like the perfect statement game for the Vikings with Cousins in the fold and I think they not only cover, but silence the Lambeau crowd with an upset victory.
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