The Week 6 college football schedule features at least one game each night, which began Tuesday and runs through the entire Saturday slate. The highlight is Saturday’s SEC top-10 battle between No. 2 Georgia and No. 6 Alabama in Tuscaloosa, Alabama. Both traditional powers are off to impressive undefeated starts, and the Week 6 college football odds show virtually no gap between them as Alabama is -1.5 at home. Both teams are 4-1 ATS this season, while Bama has won three of the last four meetings. Claim Latest Polymarket CBSSPORTS Promo Code to Get $25 Bonus After $10 Transactions:
Other lines of note from Week 6 of college football include Oregon (-11.5) vs. UCLA in a top-25 matchup, Texas (-8.5) vs. Oklahoma in the Red River rivalry and LSU (-8.5) at Kentucky. Before you lock in any Week 6 college football picks on these or other matchups, be sure to check out the latest college football predictions from SportsLine’s proven model.
The model simulates each FBS game 10,000 times. He enters Week 6 on a profitable 40-35 run on all top-rated college football picks on betting sites. Anyone tracking their picks on college football betting sites could have seen solid returns.
Now, he’s turned his attention to the latest college football odds for Week 6 and has locked in picks for every FBS matchup. Head here to see each choice.
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Best College Football Predictions for Week 6
One of the top Week 6 college football picks the model recommends for best betting apps: Arkansas (+13.5, 50.5) keeps it within double digits at home against No. 15 Tennessee in a 4:15 p.m. ET game Saturday. The Razorbacks have struggled so far, but showed signs of improvement in Week 4 against Tulsa, winning 34-6 despite being only 7-point favorites in that one. The Vols are tough on defense, but lacked explosiveness on offense, especially in the passing game. The model predicts a one score win for Tennessee as the Razorbacks cover well over 60% of the time.
Another Week 6 prediction: Nebraska (+7.5, 51.5) covers at home against No. 7 Indiana in the noon ET kickoff Saturday. Indiana wins, but doesn’t quite dominate in the same way the Hoosiers did during their national championship last year. They are just 1-4 ATS, including a close win over Northwestern in Week 4. Nebraska, meanwhile, is 4-1 ATS this season as the Cornhuskers post back-to-back wins and covers in the Big Ten. The model projects a 4-point game since Nebraska covers nearly 60% of the time. Find out what other choices the model likes here.
How to make college football picks for Week 6
The model also asked who wins and covers every college football game in Week 6, and it calls for several major upsets. You can only get every pick for every game on SportsLine.
So which college football picks can you make with confidence and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model on a 40-35 run, and find out.
College football odds for notable Week 6 matchups
See the complete Week 6 college football picks, odds and predictions here
(odds are subject to change)
Thursday October 8
Missouri State at Western Kentucky (-2.5, 56.5)
Sam Houston at Liberty (-13.5, 52.5)
South Alabama at Arkansas St. (-1.5, 58.5)
South Florida at UTSA (-7, 50.5)
Friday October 9
Florida State at Louisville (-3.5, 59.5)
Iowa at Washington (-3, 41.5)
Washington Street to Utah Street (-5.5, 43.5)
Wyoming at San Jose St. (-6, 43.5)
Iowa Street at BYU (-10.5, 46.5)
Saturday October 10
Indiana at Nebraska (+7.5, 51.5)
Texas A&M at Missouri (-3.5, 48.5)
South Carolina vs. Florida (-12.5, 61.5)
Ole Miss at Vanderbilt (+9.5, 58.5)
Stanford at Notre Dame (-37.5, 53.5)
Texas at Oklahoma (+8.5, 39.5)
UCLA at Oregon (-11.5, 59.5)
Maryland at Ohio State (-34.5, 56.5)
Tennessee at Arkansas (+13.5, 50.5)
LSU at Kentucky (+8.5, 54.5)
Georgia at Alabama (-1.5, 55.5)
USC at Penn State (-1.5, 54.5)
Minnesota at Purdue (+2.5, 50.5)
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