The NFL’s Week 3 schedule includes several contests that could be affected by travel, including two West Coast teams having a 1 p.m. ET kickoff on the East Coast. The Chargers will visit the Bills, with Buffalo as a 7-point favorite according to the Week 3 NFL odds, while the Seahawks will visit the Commanders, where Seattle is a 7.5-point favorite. Washington will be without Jayden Daniels (elbow) for an extended period, while Seattle quarterback Sam Darnold does not carry an injury designation. Claim Latest Polymarket CBSSPORTS Promo Code to Get $50 Bonus After $10 Transactions:
However, no pair of teams will have to travel as much as Dallas and especially Baltimore. Cowboys vs. Ravens will take place in Rio de Janeiro, Brazil in the first ever NFL game in Rio. The Cowboys are the designated home team, but you’ll need to back them as 3.5-point underdogs with your Week 3 NFL bets. All updated Week 3 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 3 NFL picks now.
The model, which simulates every NFL game 10,000 times, has increased by more than $7,000 for $100 players at betting sites on top-rated NFL picks since its inception. The model enters Week 3 of the 2026 NFL season with a 53-41 record on top-rated picks dating back to 2024. Anyone tracking their picks on NFL betting sites could have seen solid returns.
Now he has turned his attention to the latest NFL Week 3 odds and NFL betting lines and has locked in the betting picks for every NFL game. Head here to see each choice.
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Best NFL Predictions for Week 3
We can offer you one of the model’s best Week 3 NFL picks for the best betting apps is that the Lions (-6.5, 48.5) cover the Jets in kickoff Sunday at 1 p.m. ET. Detroit has a rest advantage after losing on Thursday, but Dan Campbell showed the ability to get the most out of his players after a loss. Detroit is 12-3 ATS after a loss since 2023, with that 80% coverage rate the best in the NFL. In the model, Detroit prevails on the spread well over 60% of the time. Find out which other teams to choose here.
Another of his NFL predictions for Week 3: 49ers (-8.5, 47.5) cover Cardinals at home. San Francisco should cover the spread in over 50% of simulations, as they appear to be arguably the best team in the league through two weeks. The Niners are the only team to rank in the top 5 in both offense and defense, also ranking in the top five in red zone performance on both ends of the court. Arizona is coming off a 24-point home loss to backup QB Seattle, and the Cards are bottom 10 in rushing and passing offense. San Francisco wins by double digits according to the model, with the Over hitting nearly 60% of the time. Find out which other teams to choose here.
How to make NFL Week 3 picks
The model also asked who wins and covers in every other game on the NFL’s Week 3 schedule and just revealed five A-rated spread picks, potentially giving you a huge payday. You can only get every pick for every game on SportsLine.
So which Week 3 NFL picks can you make with confidence, and which five A-rated picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 3 NFL Betting Odds, Lines, Spreads and Scores
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