The NFL Week 4 odds board is the last in a while with 16 games as the byes begin in Week 5. But before that, the league makes its first trip to London with Colts vs Commanders, which has Indy favored by 3.5 points. Also on Sunday, there will be just two division contests, with Patriots vs. Bills (-6.5) and Chiefs vs. Raiders (+4.5). However, Monday will have a divisional game, which also serves as an anniversary game. The Saints are 2.5-point favorites over the Falcons, according to NFL Week 4 spreads, because it’s the 20th anniversary of “Domecoming” in New Orleans in 2006. Claim Latest Polymarket CBSSPORTS Promo Code to Get $50 Bonus After $10 Transactions:
If you’re looking to make NFL Week 4 picks on games with heavy favorites, then two teams stand out. The Ravens are favored by 11.5 points over the winless Titans, and the Vikings are favored by 10.5 points over 0-3 Miami. All updated Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best Week 4 NFL picks now.
The model, which simulates every NFL game 10,000 times, has increased by more than $7,000 for $100 players at betting sites on top-rated NFL picks since its inception. The model enters Week 4 of the 2026 NFL season with a 54-43 record on top-rated picks dating back to 2024. Anyone tracking their picks on NFL betting sites could have seen strong returns.
Now he has turned his attention to the latest NFL Week 4 odds and NFL betting lines and has locked in the betting picks for every NFL game. Head here to see each choice.
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Best NFL Predictions for Week 4
We can offer you one of the model’s best Week 4 NFL picks for the best betting apps is that the Giants (+1.5, 44.5) cover the Cardinals in kickoff Sunday at 1 p.m. ET. Arizona’s Week 1 win over the Chargers looks less impressive each week, considering both the opponent and the fact that the Cards have allowed more than 31 points in consecutive losses since. Arizona is also just 5-9 ATS after a loss since the start of last year, while New York is winning games by the margin. The Giants lead the NFL in time of possession on offense, as well as starting field position on defense. The model has New York as a light value to cover and also likes the Over to hit 56% of the time. Find out which other teams to choose here.
Another of his Week 4 NFL predictions: Seahawks (-7, 42.5) cover against Chargers. LA forced five turnovers against the Bills on Sunday, but still came away with a loss as the Chargers have lost six in a row dating back to last year. They have scored 17 or less in all six games and now face a disgruntled Seahawks team that just saw its 12-game winning streak come to an end. That was after a cross-country flight to Washington, but the Seahawks return Sunday to Seattle, where it has been a calendar year since their last loss. Justin Herbert has 10 touchdowns against 11 turnovers in his last 10 games overall, while Seattle is expected to cover the spread in nearly 60% of simulations, with the Over hitting more than 60% of the time. Find out which other teams to choose here.
How to Make Week 4 NFL Picks
The model also asked who wins and covers in every other game on the NFL’s Week 4 schedule and just revealed five teams that are projected to win by double digits, potentially giving you a huge payday with the alternate lines. You can only get every pick for every game on SportsLine.
So which Week 4 NFL picks can you make with confidence, and which five picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 4 NFL Betting Odds, Lines, Spreads and Scores
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